NeuroNanotechnology to Cure Criminality and Mental Illness July 20t= h -- Terasem Annual Workshop on Geoethical Nanotechnology, Lincoln, Vermont </ti= tle>  <link rel=3DPresentation-XML href=3D"NeuronanotechnologytoCureCriminalityandMentalIllness_files/pres.xml= "> <meta name=3DDescription content=3D"7/17/2006: July 20, 2006—Terasem Annual Workshop on Geoet= hical Nanotechnology, Lincoln, Vermont "> <meta http-equiv=3Dexpires content=3D0> <![if !ppt]><script>  </script><![endif]> </head> <body> <script></script><font face=3DArial size=3D2><b> <p>This presentation contains content that your browser may not be able to = show properly. 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href=3D"../NeuronanotechnologytoCureCriminalityandMentalIllness.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>NeuroNanotechnology to Cure Criminality and Mental Illness July 20t= h -- Terasem Annual Workshop on Geoethical Nanotechnology, Lincoln, Vermont </ti= tle> <![if IE]> <base href=3D"file:///C:\1EF8A2D3\NeuronanotechnologytoCureCriminalityandMentalIl= lness_files\slide0001.htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"7/17/2006: July 20, 2006—Terasem Annual Workshop on Geoet= hical Nanotechnology, Lincoln, Vermont "> <link rel=3DStylesheet href=3D"master04_stylesheet.css"> <![if !ppt]> <style> .CB {color:white;} .CT {color:#FFCC66;} </style> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"2"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:blue;clip:rect(0%,= 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#0000ff,#ffffff,#000000,#ffcc66,#00ffff,#3366ff,#ff0033,#ffff00" masterhref=3D"master05.xml"> <p:shaperange href=3D"master05.xml#_x0000_s4097"/><![if !vml]><img src=3D"master05_background.gif" v:shapes=3D"_x0000_s4097" style=3D'positio= n:absolute; top:0%;left:0%;width:100.0%;height:100.0%'><![endif]><![if !ppt]><p:shaper= ange href=3D"master05.xml#_x0000_s4098"/><![if !vml]><img border=3D0 v:shapes=3D"_x0000_s4098,_x0000_s4099,_x0000_s4100" src=3D"master05_image0= 01.gif" style=3D'position:absolute;top:22.5%;left:2.05%;width:98.12%;height:78.0%'= ><![endif]><p:shaperange href=3D"master05.xml#_x0000_s4103"/><p:shaperange href=3D"master05.xml#_x0000_s4104"/><![endif]><p:shaperange 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left:24pt;top:27.5pt;width:684pt;height:122.5pt' filled=3D"f" fillcolor= =3D"aqua [4]" stroked=3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"blue [0]"/> <v:shadow color=3D"black [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s2050" class=3DCT><span style=3D'position:absolute; top:29.75%;left:8.42%;width:83.14%;height:9.25%'><br> </span><span style=3D'position:absolute;top:39.5%;left:2.24%;width:95.88%; height:6.0%'><span style=3D'font-size:64%;color:yellow;mso-color-index:7'>= <i>July 20, 2006—Terasem Annual Workshop on </i></span></span><span style=3D'position:absolute;top:45.75%;left:2.43%;width:95.31%;height:6.0%'= ><span style=3D'font-size:64%;color:yellow;mso-color-index:7'><i>Geoethical Nanotechnology, Lincoln, Vermont</i></span><span style=3D'font-size:64%; color:#000066'> </span></span></div> <div v:shape=3D"_x0000_s2051" class=3DCB> <div style=3D'position:absolute;top:66.25%;left:9.36%;width:79.77%;height:= 6.0%'><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>Nancy J. Woolf, Ph.D. </span></div> <div style=3D'position:absolute;top:73.75%;left:9.36%;width:79.77%;height:= 6.0%'><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'><i>Department of Psychology </i></span></div> <div style=3D'position:absolute;top:81.25%;left:7.11%;width:84.26%;height:= 6.0%'><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'><i>University of California, Los Angeles, CA </i></span></div> <div style=3D'position:absolute;top:88.5%;left:9.36%;width:79.77%;height:6= .0%'><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto;color:#FF0033; mso-color-index:6'><u>n</u></span><span style=3D'font-family:Arial;font-si= ze: 88%;text-shadow:auto'><p:onmouseclick hyperlinktype=3D"url" href=3D"mailto:Nwoolf@ucla.edu"/><a href=3D"mailto:Nwoolf@ucla.edu" target=3D"_parent" onclick=3D"window.event.cancelBubble=3Dtrue;">woolf@ucl= a.edu</a></span><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto;display:none'>&#= 13;</span></div> <div style=3D'position:absolute;top:96.0%;left:9.36%;width:79.77%;height:6= .0%'><span style=3D'font-family:Arial;font-size:88%;mso-special-format:lastCR;display= :none'> </span></div> </div> <div v:shape=3D"_x0000_s2052" class=3DO style=3D'text-align:center;mso-lin= e-spacing: "100 50 0"'><span style=3D'position:absolute;top:6.25%;left:-2.62%;width:1= 07.11%; height:10.25%'><span style=3D'font-family:Arial;font-size:200%;text-shadow= :auto; color:#FFCC66;mso-color-index:3'>Neuronanotechnology to Cure </span></span= ><span style=3D'position:absolute;top:17.0%;left:-1.31%;width:104.3%;height:10.25= %'><span style=3D'font-family:Arial;font-size:200%;text-shadow:auto;color:#FFCC66; mso-color-index:3'>Criminality and Mental Illness</span></span></div> </p:slide></div> </body> </html> ------=_NextPart_01C6A98E.B69E84D0 Content-Location: file:///C:/1EF8A2D3/NeuronanotechnologytoCureCriminalityandMentalIllness_files/master05_background.gif Content-Transfer-Encoding: base64 Content-Type: image/gif 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xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dus-ascii"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../NeuronanotechnologytoCureCriminalityandMentalIllness.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>NeuroNanotechnology to Cure Criminality and Mental Illness July 20t= h -- Terasem Annual Workshop on Geoethical Nanotechnology, Lincoln, Vermont </ti= tle> <![if IE]> <base href=3D"file:///C:\1EF8A2D3\NeuronanotechnologytoCureCriminalityandMentalIl= lness_files\slide0002.htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"7/17/2006: In Order to Elucidate Potential Cures a Physically De= tailed Model of Mind is Needed"> <link rel=3DStylesheet href=3D"master04_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:blue;clip:rect(0%,= 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#0000ff,#ffffff,#000000,#ffcc66,#00ffff,#3366ff,#ff0033,#ffff00" masterhref=3D"master04.xml"> <p:shaperange href=3D"master04.xml#_x0000_s3073"/><![if !vml]><img src=3D"master04_background.gif" v:shapes=3D"_x0000_s3073" style=3D'positio= n:absolute; top:0%;left:0%;width:100.0%;height:100.0%'><![endif]><![if 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<p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1026" class=3DT><span style=3D'position:absolute;t= op:4.25%; left:.56%;width:98.12%;height:9.25%'>In Order to Elucidate Potential </spa= n><span style=3D'position:absolute;top:14.0%;left:4.86%;width:89.51%;height:9.25%'= >Cures a Physically Detailed </span><span style=3D'position:absolute;top:23.75%; left:5.24%;width:88.95%;height:9.25%'>Model of Mind is Needed</span></div> <div v:shape=3D"_x0000_s1027" class=3DB> <div style=3D'mso-line-spacing:"100 50 0";position:absolute;top:40.0%; left:5.99%;width:98.31%;height:6.75%'><span style=3D'position:absolute; top:0%;left:3.8%;width:96.19%;height:100.0%'><span style=3D'font-family:Ar= ial; text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#3366FF; mso-color-index:5;position:absolute;left:-3.96%;top:.22em;font-family:Wing= dings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;text-shadow= :auto'>Neural networks are part of the solution. </span></span></div> <div style=3D'mso-line-spacing:"100 50 0"'><span style=3D'position:absolut= e; top:50.74%;left:9.73%;width:98.5%;height:6.75%'><span style=3D'font-family= :Arial; text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#3366FF; mso-color-index:5;position:absolute;left:-3.8%;top:.22em;font-family:Wingd= ings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;text-shadow= :auto'>Biomolecular and biophysical approaches </span></span><span style=3D'position:absolute; top:57.75%;left:9.73%;width:103.55%;height:6.75%'><span style=3D'font-fami= ly: Arial;text-shadow:auto'>offer the most complete description of mind, </spa= n></span><span style=3D'position:absolute;top:64.75%;left:9.73%;width:100.74%;height:6.75= %'><span style=3D'font-family:Arial;text-shadow:auto'>but are in the early stages of development. </span></span></div> <div style=3D'mso-line-spacing:"100 50 0"'><span style=3D'position:absolut= e; top:75.5%;left:9.73%;width:87.82%;height:6.75%'><span style=3D'font-family= :Arial; text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#3366FF; mso-color-index:5;position:absolute;left:-4.26%;top:.22em;font-family:Wing= dings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;text-shadow= :auto'>One biomolecule of interest is the </span></span><span style=3D'position:absol= ute; top:82.5%;left:9.73%;width:87.82%;height:6.75%'><span style=3D'font-family= :Arial; text-shadow:auto'>microtubule. </span></span></div> <div style=3D'position:absolute;top:91.25%;left:5.99%;width:91.57%;height:= 6.75%'><span style=3D'mso-special-format:nobullet;display:none;color:#3366FF;mso-color-= index: 5;font-family:Wingdings;font-size:80%'>l</span><span style=3D'font-family:= Arial; mso-special-format:lastCR;display:none'> </span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C6A98E.B69E84D0 Content-Location: 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Terasem Annual Workshop on Geoethical Nanotechnology, Lincoln, Vermont </ti= tle> <![if IE]> <base href=3D"file:///C:\1EF8A2D3\NeuronanotechnologytoCureCriminalityandMentalIl= lness_files\slide0035.htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"7/17/2006: Current Approach"> <link rel=3DStylesheet href=3D"master04_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"15,39"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:blue;clip:rect(0%,= 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#0000ff,#ffffff,#000000,#ffcc66,#00ffff,#3366ff,#ff0033,#ffff00" masterhref=3D"master04.xml"> <p:shaperange href=3D"master04.xml#_x0000_s3073"/><![if !vml]><img src=3D"master04_background.gif" v:shapes=3D"_x0000_s3073" style=3D'positio= n:absolute; top:0%;left:0%;width:100.0%;height:100.0%'><![endif]><![if !ppt]><p:shaper= ange href=3D"master04.xml#_x0000_s3074"/><![if !vml]><img border=3D0 v:shapes=3D"_x0000_s3074,_x0000_s3075,_x0000_s3076" src=3D"master04_image0= 02.gif" style=3D'position:absolute;top:0%;left:0%;width:100.18%;height:100.5%'><![= endif]><p:shaperange href=3D"master04.xml#_x0000_s3078"/><p:shaperange href=3D"master04.xml#_x0000_s3079"/><![endif]><p:shaperange href=3D"master04.xml#_x0000_m3077"/><v:shape id=3D"_x0000_s39938" type=3D= "#_x0000_m3077" style=3D'position:absolute;left:54pt;top:42pt;width:612pt;height:90pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder 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:auto'>Define the mind as a unique interwoven </span></span><span style=3D'position:abso= lute; top:38.25%;left:9.73%;width:87.82%;height:6.75%'><span style=3D'font-famil= y: Arial;text-shadow:auto'>collection of thoughts. </span></span></div> <div style=3D'mso-line-spacing:"100 50 0"'><span style=3D'position:absolut= e; top:48.75%;left:9.73%;width:87.82%;height:6.75%'><span style=3D'font-famil= y: Arial;text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#33= 66FF; mso-color-index:5;position:absolute;left:-4.26%;top:.22em;font-family:Wing= dings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;text-shadow= :auto'>Understand the biomolecular and </span></span><span style=3D'position:absolute;top:56= .0%; left:9.73%;width:100.74%;height:6.75%'><span style=3D'font-family:Arial; text-shadow:auto'>biophysical nature of an individual thought. </span= ></span></div> <div style=3D'mso-line-spacing:"100 50 0"'><span style=3D'position:absolut= e; top:66.5%;left:9.73%;width:102.62%;height:6.75%'><span style=3D'font-famil= y: Arial;text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#33= 66FF; mso-color-index:5;position:absolute;left:-3.64%;top:.22em;font-family:Wing= dings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;text-shadow= :auto'>Apply neuronanotechnology to find cures to </span></span><span style=3D'position= :absolute; top:73.75%;left:9.73%;width:87.82%;height:6.75%'><span style=3D'font-famil= y: Arial;text-shadow:auto'>mental illness. </span></span></div> <div style=3D'position:absolute;top:82.25%;left:5.99%;width:91.57%;height:= 6.75%'><span style=3D'position:absolute;top:0%;left:4.08%;width:95.91%;height:100.0%'><= span style=3D'font-family:Arial;text-shadow:auto;visibility:hidden'><span class= =3DBB style=3D'position:absolute;left:-4.26%'>l</span></span><span style=3D'font= -family: Arial;text-shadow:auto;mso-special-format:lastCR;display:none'> </span= ></span></div> </div> 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o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><p:shaperange href=3D"master04.xml#_x0000_m3081"/><v:shape id=3D"_x0000_s34819" type=3D= "#_x0000_m3081" style=3D'position:absolute;left:30pt;top:132pt;width:666pt;height:324pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s34818" class=3DT><span style=3D'position:absolute; top:1.5%;left:2.24%;width:96.44%;height:10.25%'><span style=3D'font-size:1= 09%'>Arguments for Subsynaptic </span></span><span style=3D'position:absolute;top:12.25%; left:4.3%;width:92.32%;height:10.25%'><span style=3D'font-size:109%'>Stora= ge of Memory</span></span></div> <div v:shape=3D"_x0000_s34819" class=3DB> <div style=3D'mso-line-spacing:"90 90 0"'><span style=3D'position:absolute; top:25.0%;left:8.98%;width:86.89%;height:6.0%'><span style=3D'font-family:= Arial; font-size:88%;text-shadow:auto'><span style=3D'mso-special-format:bullet; color:#3366FF;mso-color-index:5;position:absolute;left:-4.31%;top:.22em; font-family:Wingdings;font-size:80%'>l</span></span><span style=3D'font-fa= mily: Arial;font-size:88%;text-shadow:auto'>Synapses (many on dendrite spines) a= re </span></span><span style=3D'position:absolute;top:30.5%;left:8.98%;width:87.45%;height:6.0%'>= <span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>transiently </s= pan><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto;color:aqua;mso-c= olor-index: 4'><i>plastic</i></span><span style=3D'font-family:Arial;font-size:88%; text-shadow:auto'>; most return to baseline. </span></span></div> <div style=3D'mso-line-spacing:"90 90 0";position:absolute;top:41.75%; left:5.24%;width:97.94%;height:6.0%'><span style=3D'position:absolute; top:0%;left:3.82%;width:96.17%;height:100.0%'><span style=3D'font-family:A= rial; font-size:88%;text-shadow:auto'><span style=3D'mso-special-format:bullet; color:#3366FF;mso-color-index:5;position:absolute;left:-3.97%;top:.22em; font-family:Wingdings;font-size:80%'>l</span></span><span style=3D'font-fa= mily: Arial;font-size:88%;text-shadow:auto'>Dendrites continue to grow as intell= ect grows. </span></span></div> <div style=3D'mso-line-spacing:"90 90 0"'><span style=3D'position:absolute; top:53.0%;left:8.98%;width:99.43%;height:6.0%'><span style=3D'font-family:= Arial; font-size:88%;text-shadow:auto'><span style=3D'mso-special-format:bullet; color:#3366FF;mso-color-index:5;position:absolute;left:-3.76%;top:.22em; font-family:Wingdings;font-size:80%'>l</span></span><span style=3D'font-fa= mily: Arial;font-size:88%;text-shadow:auto'>Microtubule matrices inside dendrites determine </span></span><span style=3D'position:absolute;top:58.5%;left:8.= 98%; width:99.81%;height:6.0%'><span style=3D'font-family:Arial;font-size:88%; text-shadow:auto'>synaptic strength because they control </span><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto;color:aqua;mso-c= olor-index: 4'><i>transport</i></span><span style=3D'font-family:Arial;font-size:88%; text-shadow:auto'> </span></span><span style=3D'position:absolute;top:64.2= 5%; left:8.98%;width:86.89%;height:6.0%'><span style=3D'font-family:Arial; font-size:88%;text-shadow:auto'>and </span><span style=3D'font-family:Aria= l; font-size:88%;text-shadow:auto;color:aqua;mso-color-index:4'><i>local prot= ein translation</i></span><span style=3D'font-family:Arial;font-size:88%;text-= shadow: auto'>. </span></span></div> <div style=3D'mso-line-spacing:"90 90 0"'><span style=3D'position:absolute; top:75.25%;left:8.98%;width:93.44%;height:6.0%'><span style=3D'font-family= :Arial; font-size:88%;text-shadow:auto'><span style=3D'mso-special-format:bullet; color:#3366FF;mso-color-index:5;position:absolute;left:-4.0%;top:.22em; font-family:Wingdings;font-size:80%'>l</span></span><span style=3D'font-fa= mily: Arial;font-size:88%;text-shadow:auto'>Microtubules store information via patterns of </span></span><span style=3D'position:absolute;top:81.0%;left:= 8.98%; width:94.94%;height:6.0%'><span style=3D'font-family:Arial;font-size:88%; text-shadow:auto'>microtubule-associated proteins (e.g., MAP2); </span></s= pan><span style=3D'position:absolute;top:86.5%;left:8.98%;width:103.55%;height:6.0%'= ><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>these patterns = are determined by </span><span style=3D'font-family:Arial;font-size:88%;text-s= hadow: auto;color:aqua;mso-color-index:4'><i>tubulin isotypes</i></span><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>. </span></span= ><span style=3D'position:absolute;top:92.25%;left:8.98%;width:98.31%;height:6.0%'= ><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>But how does th= is translate into a mental state? </span></span></div> <div style=3D'mso-line-spacing:"90 20 0";position:absolute;top:99.0%;left:= 5.24%; width:90.63%;height:6.0%'><span style=3D'position:absolute;top:0%;left:4.1= 3%; width:95.86%;height:100.0%'><span style=3D'font-family:Arial;font-size:88%; text-shadow:auto;visibility:hidden'><span style=3D'mso-special-format:bull= et; color:#3366FF;mso-color-index:5;position:absolute;left:-4.31%;font-family: Wingdings;font-size:80%'>l</span></span><span style=3D'font-family:Arial; font-size:88%;text-shadow:auto;mso-special-format:lastCR;display:none'>= 3;</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C6A98E.B69E84D0 Content-Location: file:///C:/1EF8A2D3/NeuronanotechnologytoCureCriminalityandMentalIllness_files/slide0004.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" 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class=3DO style=3D'position:absolute;top:39.0%;left:0%;width:101.12%;height:35.25%; white-space:nowrap'> <div style=3D'text-align:center;mso-line-spacing:"100 50 0"'><span style=3D'position:absolute;top:0%;left:0%;width:100.0%;height:24.11%'><span style=3D'font-family:Arial;font-size:167%;text-shadow:auto;color:aqua; mso-color-index:4'><i>(e.g. What happens when animals </i></span></span><s= pan style=3D'position:absolute;top:24.82%;left:7.59%;width:84.62%;height:24.11= %'><span style=3D'font-family:Arial;font-size:167%;text-shadow:auto;color:aqua; mso-color-index:4'><i>perform tasks such as fear </i></span></span><span style=3D'position:absolute;top:50.35%;left:7.59%;width:84.62%;height:24.11= %'><span style=3D'font-family:Arial;font-size:167%;text-shadow:auto;color:aqua; mso-color-index:4'><i>conditioning, avoidance, and </i></span></span><span style=3D'position:absolute;top:75.17%;left:7.59%;width:84.62%;height:24.11= %'><span 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style=3D'mso-margin-left-alt:864'></div> <div class=3DCB3 style=3D'mso-margin-left-alt:1104'></div> <div class=3DCB4 style=3D'mso-margin-left-alt:1392'></div> <div class=3DCB style=3D'text-align:left;mso-line-spacing:"100 50 0";mso-m= argin-left-alt: 384'><span style=3D'position:absolute;top:24.0%;left:12.73%;width:94.56%; height:6.0%'><span style=3D'font-family:Arial;font-size:88%;color:aqua; text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#FFCC66; mso-color-index:3;position:absolute;left:-7.12%;top:.22em;font-family:Wing= dings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;font-size:8= 8%; text-shadow:auto;color:aqua'>Fear conditioning</span><span style=3D'font-f= amily: Arial;font-size:88%;text-shadow:auto'> increases the breakdown of </span><= /span><span style=3D'position:absolute;top:30.25%;left:12.73%;width:81.46%;height:6.0%= '><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>MAP2 and tubuli= n and also alters the </span></span><span style=3D'position:absolute;top:36.5%; left:12.73%;width:91.94%;height:6.0%'><span style=3D'font-family:Arial; font-size:88%;text-shadow:auto'>phosphorylation state </span><span style=3D'font-family:Arial;font-size:75%;text-shadow:auto;color:yellow; mso-color-index:7'>(</span><span style=3D'font-family:Arial;font-size:75%; text-shadow:auto;color:yellow;mso-color-index:7'><i>Woolf et al., 1999; Wo= olf, </i></span></span><span style=3D'position:absolute;top:42.5%;left:12.73%; width:81.46%;height:5.25%'><span style=3D'font-family:Arial;font-size:75%; text-shadow:auto;color:yellow;mso-color-index:7'><i>1998; Woolf et al., 19= 94</i></span><span style=3D'font-family:Arial;font-size:75%;text-shadow:auto;color:yellow; mso-color-index:7'>).</span><span style=3D'font-family:Arial;font-size:75%; text-shadow:auto'> </span></span></div> <div class=3DCB style=3D'text-align:left;mso-line-spacing:"100 50 0";mso-m= argin-left-alt: 384'><span style=3D'position:absolute;top:51.0%;left:12.73%;width:91.57%; height:6.0%'><span style=3D'font-family:Arial;font-size:88%;text-shadow:au= to'><span style=3D'mso-special-format:bullet;color:#FFCC66;mso-color-index:3;positio= n: absolute;left:-7.36%;top:.22em;font-family:Wingdings;font-size:80%'>l</spa= n></span><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>Knockout studie= s show MAP2 is essential to </span></span><span style=3D'position:absolute;top:57= .25%; left:12.73%;width:81.46%;height:6.0%'><span style=3D'font-family:Arial; font-size:88%;text-shadow:auto'>fear conditioning </span><span style=3D'font-family:Arial;font-size:75%;text-shadow:auto;color:yellow; mso-color-index:7'>(</span><span style=3D'font-family:Arial;font-size:75%; text-shadow:auto;color:yellow;mso-color-index:7'><i>Khuchua et al., 2003</= i></span><span style=3D'font-family:Arial;font-size:75%;text-shadow:auto;color:yellow; mso-color-index:7'>). </span></span></div> <div class=3DCB style=3D'text-align:left;mso-line-spacing:"100 50 0";mso-m= argin-left-alt: 384'><span style=3D'position:absolute;top:66.75%;left:12.73%;width:91.19%; height:6.0%'><span style=3D'font-family:Arial;font-size:88%;color:aqua; text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#FFCC66; mso-color-index:3;position:absolute;left:-7.39%;top:.22em;font-family:Wing= dings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;font-size:8= 8%; text-shadow:auto;color:aqua'>Passive avoidance</span><span style=3D'font-f= amily: Arial;font-size:88%;text-shadow:auto'> affects the distribution of </span>= </span><span style=3D'position:absolute;top:73.0%;left:12.73%;width:95.69%;height:6.0%'= ><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>MAP2-rich modul= es of cortex </span><span style=3D'font-family:Arial;font-size:75%;text-shadow:a= uto; color:yellow;mso-color-index:7'>(</span><span style=3D'font-family:Arial; font-size:75%;text-shadow:auto;color:yellow;mso-color-index:7'><i>Van der = Zee et al., </i></span></span><span style=3D'position:absolute;top:79.0%;left:= 12.73%; width:81.46%;height:5.25%'><span style=3D'font-family:Arial;font-size:75%; text-shadow:auto;color:yellow;mso-color-index:7'><i>1994</i></span><span style=3D'font-family:Arial;font-size:75%;text-shadow:auto;color:yellow; mso-color-index:7'>). </span></span></div> <div class=3DCB style=3D'text-align:left;mso-line-spacing:"100 50 0";mso-m= argin-left-alt: 384'><span style=3D'position:absolute;top:87.5%;left:12.73%;width:95.31%; height:6.0%'><span style=3D'font-family:Arial;font-size:88%;color:aqua; text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#FFCC66; mso-color-index:3;position:absolute;left:-7.07%;top:.22em;font-family:Wing= dings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;font-size:8= 8%; text-shadow:auto;color:aqua'>Spatial and working memory</span><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'> are enhanced b= y </span></span><span style=3D'position:absolute;top:93.75%;left:12.73%;width:89.32%;height:6.0%= '><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>overexpression = of kinesin </span><span style=3D'font-family:Arial;font-size:75%;text-shadow:= auto; color:yellow;mso-color-index:7'>(</span><span style=3D'font-family:Arial; font-size:75%;text-shadow:auto;color:yellow;mso-color-index:7'><i>Wong et = al., 2002</i></span><span style=3D'font-family:Arial;font-size:75%;text-shadow:= auto; color:yellow;mso-color-index:7'>).</span></span></div> </div> <div v:shape=3D"_x0000_s20484" class=3DCT><span style=3D'position:absolute; top:-.75%;left:.93%;width:98.12%;height:10.25%'><span style=3D'font-size:1= 09%'>MAP2 and Tubulin Are </span></span><span style=3D'position:absolute;top:10.0%; left:-8.23%;width:116.85%;height:10.25%'><span style=3D'font-size:109%'>Re= organized with Memory Tasks</span><span style=3D'font-size:91%'> </span><span style=3D'font-size:73%;mso-special-format:lastCR;display:none'> </span= ></span></div> </p:slide></div> </body> </html> ------=_NextPart_01C6A98E.B69E84D0 Content-Location: file:///C:/1EF8A2D3/NeuronanotechnologytoCureCriminalityandMentalIllness_files/slide0019.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dus-ascii"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../NeuronanotechnologytoCureCriminalityandMentalIllness.htm"> <link rel=3DPreview href=3Dpreview.wmf>  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src=3D"slide0019_image005.gif" style=3D'position:absolute;top:0%;left:80.8= 9%; width:19.47%;height:5.25%'><![endif]> <div v:shape=3D"_x0000_s21507" class=3DO><span style=3D'position:absolute; top:70.0%;left:6.92%;width:109.92%;height:5.25%'><span style=3D'font-famil= y: Arial;font-size:83%;text-shadow:auto;color:aqua'>Naïve Control<span style=3D'mso-spacerun:yes'> = ; </span>Tone-Shock Paired<span style=3D'mso-spacerun:yes'> = ; </span>Tone-Shock Unpaired</span><span style=3D'color:#FF0033;mso-color-in= dex: 6'> </span></span><span style=3D'position:absolute;top:75.25%;left:6.92%; width:92.32%;height:5.25%'><span style=3D'color:#FF0033;mso-color-index:6'= ><span style=3D'mso-tab-count:1;width:10.83%'> </span> </span></span> <div style=3D'position:absolute;top:80.75%;left:6.92%;width:92.32%;height:= 6.75%'><span style=3D'color:#FF0033;mso-color-index:6'><span style=3D'mso-tab-count:3; width:32.49%'> </span><span style=3D'mso-spacerun:yes'> </span></spa= n><span style=3D'font-size:133%;color:#FF0033;mso-color-index:6'><span style=3D'ms= o-tab-count: 2;width:19.85%'> </span></span></div> </div> <div v:shape=3D"_x0000_s21508"> <div class=3DO1 style=3D'mso-margin-left-alt:576'></div> <div class=3DO2 style=3D'mso-margin-left-alt:864'></div> <div class=3DO3 style=3D'mso-margin-left-alt:1152'></div> <div class=3DO4 style=3D'mso-margin-left-alt:1440'></div> <div class=3DO style=3D'mso-line-spacing:"100 50 0";mso-margin-left-alt:28= 8'><span style=3D'position:absolute;top:78.75%;left:2.62%;width:108.05%;height:6.0%= '><span style=3D'font-family:Arial;font-size:117%;text-shadow:auto;color:yellow; mso-color-index:7'><span style=3D'mso-spacerun:yes'> &nbs= p; </span>Increased MAP2 immunostaining in hippocampal </span></span><span style=3D'position:absolute;top:85.0%;left:7.67%;width:106.17%;height:6.0%'= ><span style=3D'font-family:Arial;font-size:117%;text-shadow:auto;color:yellow; mso-color-index:7'>CA1 pyramidal cells is due to increased breakdown </spa= n></span><span style=3D'position:absolute;top:91.25%;left:7.67%;width:100.18%;height:6.0%= '><span style=3D'font-family:Arial;font-size:117%;text-shadow:auto;color:yellow; mso-color-index:7'>of these proteins (confirmed by immunoblotting).</span>= </span></div> </div> <div v:shape=3D"_x0000_s21509" class=3DO style=3D'mso-line-spacing:"100 50= 0"; position:absolute;top:1.0%;left:81.83%;width:19.66%;height:3.5%'><span style=3D'font-size:67%;text-shadow:auto'>Woolf et al., 1999</span></div> </p:slide></div> </body> </html> ------=_NextPart_01C6A98E.B69E84D0 Content-Location: file:///C:/1EF8A2D3/NeuronanotechnologytoCureCriminalityandMentalIllness_files/slide0019_image003.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAArEAAAFoBAAAAACgmBGKAAAAAmJLR0QAAKqNIzIAAAAMY21QUEpD bXAwNzEyAAAAB09tt6UAAPRsSURBVHjaXP1tsBxpdh6IdVOKtX/4Rxd6SHqpZYTw0SNpJW6ogQsM JdsR7r4faFqKDXXjVl2MZEdoBreyCkNtBMnGzczCrDYkTaMys0BtUCs26n3zziqGu6tBZSbIGEkh 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href=3D"../NeuronanotechnologytoCureCriminalityandMentalIllness.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>NeuroNanotechnology to Cure Criminality and Mental Illness July 20t= h -- Terasem Annual Workshop on Geoethical Nanotechnology, Lincoln, Vermont </ti= tle> <![if IE]> <base href=3D"file:///C:\1EF8A2D3\NeuronanotechnologytoCureCriminalityandMentalIl= lness_files\slide0001.htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"7/17/2006: July 20, 2006—Terasem Annual Workshop on Geoet= hical Nanotechnology, Lincoln, Vermont "> <link rel=3DStylesheet href=3D"master04_stylesheet.css"> <![if !ppt]> <style> .CB {color:white;} .CT {color:#FFCC66;} </style> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"2"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:blue;clip:rect(0%,= 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#0000ff,#ffffff,#000000,#ffcc66,#00ffff,#3366ff,#ff0033,#ffff00" masterhref=3D"master05.xml"> <p:shaperange href=3D"master05.xml#_x0000_s4097"/><![if !vml]><img src=3D"master05_background.gif" v:shapes=3D"_x0000_s4097" style=3D'positio= n:absolute; top:0%;left:0%;width:100.0%;height:100.0%'><![endif]><![if !ppt]><p:shaper= ange href=3D"master05.xml#_x0000_s4098"/><![if !vml]><img border=3D0 v:shapes=3D"_x0000_s4098,_x0000_s4099,_x0000_s4100" src=3D"master05_image0= 01.gif" style=3D'position:absolute;top:22.5%;left:2.05%;width:98.12%;height:78.0%'= ><![endif]><p:shaperange href=3D"master05.xml#_x0000_s4103"/><p:shaperange href=3D"master05.xml#_x0000_s4104"/><![endif]><p:shaperange 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left:24pt;top:27.5pt;width:684pt;height:122.5pt' filled=3D"f" fillcolor= =3D"aqua [4]" stroked=3D"f" strokecolor=3D"white [1]"> <v:fill color2=3D"blue [0]"/> <v:shadow color=3D"black [2]"/> <v:textbox style=3D'mso-fit-shape-to-text:t'/> </v:shape> <div v:shape=3D"_x0000_s2050" class=3DCT><span style=3D'position:absolute; top:29.75%;left:8.42%;width:83.14%;height:9.25%'><br> </span><span style=3D'position:absolute;top:39.5%;left:2.24%;width:95.88%; height:6.0%'><span style=3D'font-size:64%;color:yellow;mso-color-index:7'>= <i>July 20, 2006—Terasem Annual Workshop on </i></span></span><span style=3D'position:absolute;top:45.75%;left:2.43%;width:95.31%;height:6.0%'= ><span style=3D'font-size:64%;color:yellow;mso-color-index:7'><i>Geoethical Nanotechnology, Lincoln, Vermont</i></span><span style=3D'font-size:64%; color:#000066'> </span></span></div> <div v:shape=3D"_x0000_s2051" class=3DCB> <div style=3D'position:absolute;top:66.25%;left:9.36%;width:79.77%;height:= 6.0%'><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>Nancy J. Woolf, Ph.D. </span></div> <div style=3D'position:absolute;top:73.75%;left:9.36%;width:79.77%;height:= 6.0%'><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'><i>Department of Psychology </i></span></div> <div style=3D'position:absolute;top:81.25%;left:7.11%;width:84.26%;height:= 6.0%'><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'><i>University of California, Los Angeles, CA </i></span></div> <div style=3D'position:absolute;top:88.5%;left:9.36%;width:79.77%;height:6= .0%'><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto;color:#FF0033; mso-color-index:6'><u>n</u></span><span style=3D'font-family:Arial;font-si= ze: 88%;text-shadow:auto'><p:onmouseclick hyperlinktype=3D"url" href=3D"mailto:Nwoolf@ucla.edu"/><a href=3D"mailto:Nwoolf@ucla.edu" target=3D"_parent" onclick=3D"window.event.cancelBubble=3Dtrue;">woolf@ucl= a.edu</a></span><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto;display:none'>&#= 13;</span></div> <div style=3D'position:absolute;top:96.0%;left:9.36%;width:79.77%;height:6= .0%'><span style=3D'font-family:Arial;font-size:88%;mso-special-format:lastCR;display= :none'> </span></div> </div> <div v:shape=3D"_x0000_s2052" class=3DO style=3D'text-align:center;mso-lin= e-spacing: "100 50 0"'><span style=3D'position:absolute;top:6.25%;left:-2.62%;width:1= 07.11%; height:10.25%'><span style=3D'font-family:Arial;font-size:200%;text-shadow= :auto; color:#FFCC66;mso-color-index:3'>Neuronanotechnology to Cure </span></span= ><span style=3D'position:absolute;top:17.0%;left:-1.31%;width:104.3%;height:10.25= %'><span style=3D'font-family:Arial;font-size:200%;text-shadow:auto;color:#FFCC66; mso-color-index:3'>Criminality and Mental Illness</span></span></div> </p:slide></div> </body> </html> ------=_NextPart_01C6A98E.B69E84D0 Content-Location: file:///C:/1EF8A2D3/NeuronanotechnologytoCureCriminalityandMentalIllness_files/master05_background.gif Content-Transfer-Encoding: base64 Content-Type: image/gif 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xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dus-ascii"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../NeuronanotechnologytoCureCriminalityandMentalIllness.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>NeuroNanotechnology to Cure Criminality and Mental Illness July 20t= h -- Terasem Annual Workshop on Geoethical Nanotechnology, Lincoln, Vermont </ti= tle> <![if IE]> <base href=3D"file:///C:\1EF8A2D3\NeuronanotechnologytoCureCriminalityandMentalIl= lness_files\slide0002.htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"7/17/2006: In Order to Elucidate Potential Cures a Physically De= tailed Model of Mind is Needed"> <link rel=3DStylesheet href=3D"master04_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:blue;clip:rect(0%,= 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#0000ff,#ffffff,#000000,#ffcc66,#00ffff,#3366ff,#ff0033,#ffff00" masterhref=3D"master04.xml"> <p:shaperange href=3D"master04.xml#_x0000_s3073"/><![if !vml]><img src=3D"master04_background.gif" v:shapes=3D"_x0000_s3073" style=3D'positio= n:absolute; top:0%;left:0%;width:100.0%;height:100.0%'><![endif]><![if 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<p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s1026" class=3DT><span style=3D'position:absolute;t= op:4.25%; left:.56%;width:98.12%;height:9.25%'>In Order to Elucidate Potential </spa= n><span style=3D'position:absolute;top:14.0%;left:4.86%;width:89.51%;height:9.25%'= >Cures a Physically Detailed </span><span style=3D'position:absolute;top:23.75%; left:5.24%;width:88.95%;height:9.25%'>Model of Mind is Needed</span></div> <div v:shape=3D"_x0000_s1027" class=3DB> <div style=3D'mso-line-spacing:"100 50 0";position:absolute;top:40.0%; left:5.99%;width:98.31%;height:6.75%'><span style=3D'position:absolute; top:0%;left:3.8%;width:96.19%;height:100.0%'><span style=3D'font-family:Ar= ial; text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#3366FF; mso-color-index:5;position:absolute;left:-3.96%;top:.22em;font-family:Wing= dings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;text-shadow= :auto'>Neural networks are part of the solution. </span></span></div> <div style=3D'mso-line-spacing:"100 50 0"'><span style=3D'position:absolut= e; top:50.74%;left:9.73%;width:98.5%;height:6.75%'><span style=3D'font-family= :Arial; text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#3366FF; mso-color-index:5;position:absolute;left:-3.8%;top:.22em;font-family:Wingd= ings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;text-shadow= :auto'>Biomolecular and biophysical approaches </span></span><span style=3D'position:absolute; top:57.75%;left:9.73%;width:103.55%;height:6.75%'><span style=3D'font-fami= ly: Arial;text-shadow:auto'>offer the most complete description of mind, </spa= n></span><span style=3D'position:absolute;top:64.75%;left:9.73%;width:100.74%;height:6.75= %'><span style=3D'font-family:Arial;text-shadow:auto'>but are in the early stages of development. </span></span></div> <div style=3D'mso-line-spacing:"100 50 0"'><span style=3D'position:absolut= e; top:75.5%;left:9.73%;width:87.82%;height:6.75%'><span style=3D'font-family= :Arial; text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#3366FF; mso-color-index:5;position:absolute;left:-4.26%;top:.22em;font-family:Wing= dings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;text-shadow= :auto'>One biomolecule of interest is the </span></span><span style=3D'position:absol= ute; top:82.5%;left:9.73%;width:87.82%;height:6.75%'><span style=3D'font-family= :Arial; text-shadow:auto'>microtubule. </span></span></div> <div style=3D'position:absolute;top:91.25%;left:5.99%;width:91.57%;height:= 6.75%'><span style=3D'mso-special-format:nobullet;display:none;color:#3366FF;mso-color-= index: 5;font-family:Wingdings;font-size:80%'>l</span><span style=3D'font-family:= Arial; mso-special-format:lastCR;display:none'> </span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C6A98E.B69E84D0 Content-Location: 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Terasem Annual Workshop on Geoethical Nanotechnology, Lincoln, Vermont </ti= tle> <![if IE]> <base href=3D"file:///C:\1EF8A2D3\NeuronanotechnologytoCureCriminalityandMentalIl= lness_files\slide0035.htm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"7/17/2006: Current Approach"> <link rel=3DStylesheet href=3D"master04_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"15,39"/> </o:shapelayout> </head> <body lang=3DEN-US style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:blue;clip:rect(0%,= 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#0000ff,#ffffff,#000000,#ffcc66,#00ffff,#3366ff,#ff0033,#ffff00" masterhref=3D"master04.xml"> <p:shaperange href=3D"master04.xml#_x0000_s3073"/><![if !vml]><img src=3D"master04_background.gif" v:shapes=3D"_x0000_s3073" style=3D'positio= n:absolute; top:0%;left:0%;width:100.0%;height:100.0%'><![endif]><![if !ppt]><p:shaper= ange href=3D"master04.xml#_x0000_s3074"/><![if !vml]><img border=3D0 v:shapes=3D"_x0000_s3074,_x0000_s3075,_x0000_s3076" src=3D"master04_image0= 02.gif" style=3D'position:absolute;top:0%;left:0%;width:100.18%;height:100.5%'><![= endif]><p:shaperange href=3D"master04.xml#_x0000_s3078"/><p:shaperange href=3D"master04.xml#_x0000_s3079"/><![endif]><p:shaperange href=3D"master04.xml#_x0000_m3077"/><v:shape id=3D"_x0000_s39938" type=3D= "#_x0000_m3077" style=3D'position:absolute;left:54pt;top:42pt;width:612pt;height:90pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder 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:auto'>Define the mind as a unique interwoven </span></span><span style=3D'position:abso= lute; top:38.25%;left:9.73%;width:87.82%;height:6.75%'><span style=3D'font-famil= y: Arial;text-shadow:auto'>collection of thoughts. </span></span></div> <div style=3D'mso-line-spacing:"100 50 0"'><span style=3D'position:absolut= e; top:48.75%;left:9.73%;width:87.82%;height:6.75%'><span style=3D'font-famil= y: Arial;text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#33= 66FF; mso-color-index:5;position:absolute;left:-4.26%;top:.22em;font-family:Wing= dings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;text-shadow= :auto'>Understand the biomolecular and </span></span><span style=3D'position:absolute;top:56= .0%; left:9.73%;width:100.74%;height:6.75%'><span style=3D'font-family:Arial; text-shadow:auto'>biophysical nature of an individual thought. </span= ></span></div> <div style=3D'mso-line-spacing:"100 50 0"'><span style=3D'position:absolut= e; top:66.5%;left:9.73%;width:102.62%;height:6.75%'><span style=3D'font-famil= y: Arial;text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#33= 66FF; mso-color-index:5;position:absolute;left:-3.64%;top:.22em;font-family:Wing= dings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;text-shadow= :auto'>Apply neuronanotechnology to find cures to </span></span><span style=3D'position= :absolute; top:73.75%;left:9.73%;width:87.82%;height:6.75%'><span style=3D'font-famil= y: Arial;text-shadow:auto'>mental illness. </span></span></div> <div style=3D'position:absolute;top:82.25%;left:5.99%;width:91.57%;height:= 6.75%'><span style=3D'position:absolute;top:0%;left:4.08%;width:95.91%;height:100.0%'><= span style=3D'font-family:Arial;text-shadow:auto;visibility:hidden'><span class= =3DBB style=3D'position:absolute;left:-4.26%'>l</span></span><span style=3D'font= -family: Arial;text-shadow:auto;mso-special-format:lastCR;display:none'> </span= ></span></div> </div> 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o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"title"/></v:shape><p:shaperange href=3D"master04.xml#_x0000_m3081"/><v:shape id=3D"_x0000_s34819" type=3D= "#_x0000_m3081" style=3D'position:absolute;left:30pt;top:132pt;width:666pt;height:324pt' o:userdrawn=3D"f"> <v:fill o:detectmouseclick=3D"f"/> <v:stroke o:forcedash=3D"f"/> <o:lock v:ext=3D"edit" text=3D"f"/> <p:placeholder type=3D"body" position=3D"1"/></v:shape> <div v:shape=3D"_x0000_s34818" class=3DT><span style=3D'position:absolute; top:1.5%;left:2.24%;width:96.44%;height:10.25%'><span style=3D'font-size:1= 09%'>Arguments for Subsynaptic </span></span><span style=3D'position:absolute;top:12.25%; left:4.3%;width:92.32%;height:10.25%'><span style=3D'font-size:109%'>Stora= ge of Memory</span></span></div> <div v:shape=3D"_x0000_s34819" class=3DB> <div style=3D'mso-line-spacing:"90 90 0"'><span style=3D'position:absolute; top:25.0%;left:8.98%;width:86.89%;height:6.0%'><span style=3D'font-family:= Arial; font-size:88%;text-shadow:auto'><span style=3D'mso-special-format:bullet; color:#3366FF;mso-color-index:5;position:absolute;left:-4.31%;top:.22em; font-family:Wingdings;font-size:80%'>l</span></span><span style=3D'font-fa= mily: Arial;font-size:88%;text-shadow:auto'>Synapses (many on dendrite spines) a= re </span></span><span style=3D'position:absolute;top:30.5%;left:8.98%;width:87.45%;height:6.0%'>= <span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>transiently </s= pan><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto;color:aqua;mso-c= olor-index: 4'><i>plastic</i></span><span style=3D'font-family:Arial;font-size:88%; text-shadow:auto'>; most return to baseline. </span></span></div> <div style=3D'mso-line-spacing:"90 90 0";position:absolute;top:41.75%; left:5.24%;width:97.94%;height:6.0%'><span style=3D'position:absolute; top:0%;left:3.82%;width:96.17%;height:100.0%'><span style=3D'font-family:A= rial; font-size:88%;text-shadow:auto'><span style=3D'mso-special-format:bullet; color:#3366FF;mso-color-index:5;position:absolute;left:-3.97%;top:.22em; font-family:Wingdings;font-size:80%'>l</span></span><span style=3D'font-fa= mily: Arial;font-size:88%;text-shadow:auto'>Dendrites continue to grow as intell= ect grows. </span></span></div> <div style=3D'mso-line-spacing:"90 90 0"'><span style=3D'position:absolute; top:53.0%;left:8.98%;width:99.43%;height:6.0%'><span style=3D'font-family:= Arial; font-size:88%;text-shadow:auto'><span style=3D'mso-special-format:bullet; color:#3366FF;mso-color-index:5;position:absolute;left:-3.76%;top:.22em; font-family:Wingdings;font-size:80%'>l</span></span><span style=3D'font-fa= mily: Arial;font-size:88%;text-shadow:auto'>Microtubule matrices inside dendrites determine </span></span><span style=3D'position:absolute;top:58.5%;left:8.= 98%; width:99.81%;height:6.0%'><span style=3D'font-family:Arial;font-size:88%; text-shadow:auto'>synaptic strength because they control </span><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto;color:aqua;mso-c= olor-index: 4'><i>transport</i></span><span style=3D'font-family:Arial;font-size:88%; text-shadow:auto'> </span></span><span style=3D'position:absolute;top:64.2= 5%; left:8.98%;width:86.89%;height:6.0%'><span style=3D'font-family:Arial; font-size:88%;text-shadow:auto'>and </span><span style=3D'font-family:Aria= l; font-size:88%;text-shadow:auto;color:aqua;mso-color-index:4'><i>local prot= ein translation</i></span><span style=3D'font-family:Arial;font-size:88%;text-= shadow: auto'>. </span></span></div> <div style=3D'mso-line-spacing:"90 90 0"'><span style=3D'position:absolute; top:75.25%;left:8.98%;width:93.44%;height:6.0%'><span style=3D'font-family= :Arial; font-size:88%;text-shadow:auto'><span style=3D'mso-special-format:bullet; color:#3366FF;mso-color-index:5;position:absolute;left:-4.0%;top:.22em; font-family:Wingdings;font-size:80%'>l</span></span><span style=3D'font-fa= mily: Arial;font-size:88%;text-shadow:auto'>Microtubules store information via patterns of </span></span><span style=3D'position:absolute;top:81.0%;left:= 8.98%; width:94.94%;height:6.0%'><span style=3D'font-family:Arial;font-size:88%; text-shadow:auto'>microtubule-associated proteins (e.g., MAP2); </span></s= pan><span style=3D'position:absolute;top:86.5%;left:8.98%;width:103.55%;height:6.0%'= ><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>these patterns = are determined by </span><span style=3D'font-family:Arial;font-size:88%;text-s= hadow: auto;color:aqua;mso-color-index:4'><i>tubulin isotypes</i></span><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>. </span></span= ><span style=3D'position:absolute;top:92.25%;left:8.98%;width:98.31%;height:6.0%'= ><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>But how does th= is translate into a mental state? </span></span></div> <div style=3D'mso-line-spacing:"90 20 0";position:absolute;top:99.0%;left:= 5.24%; width:90.63%;height:6.0%'><span style=3D'position:absolute;top:0%;left:4.1= 3%; width:95.86%;height:100.0%'><span style=3D'font-family:Arial;font-size:88%; text-shadow:auto;visibility:hidden'><span style=3D'mso-special-format:bull= et; color:#3366FF;mso-color-index:5;position:absolute;left:-4.31%;font-family: Wingdings;font-size:80%'>l</span></span><span style=3D'font-family:Arial; font-size:88%;text-shadow:auto;mso-special-format:lastCR;display:none'>= 3;</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01C6A98E.B69E84D0 Content-Location: file:///C:/1EF8A2D3/NeuronanotechnologytoCureCriminalityandMentalIllness_files/slide0004.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" 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class=3DO style=3D'position:absolute;top:39.0%;left:0%;width:101.12%;height:35.25%; white-space:nowrap'> <div style=3D'text-align:center;mso-line-spacing:"100 50 0"'><span style=3D'position:absolute;top:0%;left:0%;width:100.0%;height:24.11%'><span style=3D'font-family:Arial;font-size:167%;text-shadow:auto;color:aqua; mso-color-index:4'><i>(e.g. What happens when animals </i></span></span><s= pan style=3D'position:absolute;top:24.82%;left:7.59%;width:84.62%;height:24.11= %'><span style=3D'font-family:Arial;font-size:167%;text-shadow:auto;color:aqua; mso-color-index:4'><i>perform tasks such as fear </i></span></span><span style=3D'position:absolute;top:50.35%;left:7.59%;width:84.62%;height:24.11= %'><span style=3D'font-family:Arial;font-size:167%;text-shadow:auto;color:aqua; mso-color-index:4'><i>conditioning, avoidance, and </i></span></span><span style=3D'position:absolute;top:75.17%;left:7.59%;width:84.62%;height:24.11= %'><span 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style=3D'mso-margin-left-alt:864'></div> <div class=3DCB3 style=3D'mso-margin-left-alt:1104'></div> <div class=3DCB4 style=3D'mso-margin-left-alt:1392'></div> <div class=3DCB style=3D'text-align:left;mso-line-spacing:"100 50 0";mso-m= argin-left-alt: 384'><span style=3D'position:absolute;top:24.0%;left:12.73%;width:94.56%; height:6.0%'><span style=3D'font-family:Arial;font-size:88%;color:aqua; text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#FFCC66; mso-color-index:3;position:absolute;left:-7.12%;top:.22em;font-family:Wing= dings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;font-size:8= 8%; text-shadow:auto;color:aqua'>Fear conditioning</span><span style=3D'font-f= amily: Arial;font-size:88%;text-shadow:auto'> increases the breakdown of </span><= /span><span style=3D'position:absolute;top:30.25%;left:12.73%;width:81.46%;height:6.0%= '><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>MAP2 and tubuli= n and also alters the </span></span><span style=3D'position:absolute;top:36.5%; left:12.73%;width:91.94%;height:6.0%'><span style=3D'font-family:Arial; font-size:88%;text-shadow:auto'>phosphorylation state </span><span style=3D'font-family:Arial;font-size:75%;text-shadow:auto;color:yellow; mso-color-index:7'>(</span><span style=3D'font-family:Arial;font-size:75%; text-shadow:auto;color:yellow;mso-color-index:7'><i>Woolf et al., 1999; Wo= olf, </i></span></span><span style=3D'position:absolute;top:42.5%;left:12.73%; width:81.46%;height:5.25%'><span style=3D'font-family:Arial;font-size:75%; text-shadow:auto;color:yellow;mso-color-index:7'><i>1998; Woolf et al., 19= 94</i></span><span style=3D'font-family:Arial;font-size:75%;text-shadow:auto;color:yellow; mso-color-index:7'>).</span><span style=3D'font-family:Arial;font-size:75%; text-shadow:auto'> </span></span></div> <div class=3DCB style=3D'text-align:left;mso-line-spacing:"100 50 0";mso-m= argin-left-alt: 384'><span style=3D'position:absolute;top:51.0%;left:12.73%;width:91.57%; height:6.0%'><span style=3D'font-family:Arial;font-size:88%;text-shadow:au= to'><span style=3D'mso-special-format:bullet;color:#FFCC66;mso-color-index:3;positio= n: absolute;left:-7.36%;top:.22em;font-family:Wingdings;font-size:80%'>l</spa= n></span><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>Knockout studie= s show MAP2 is essential to </span></span><span style=3D'position:absolute;top:57= .25%; left:12.73%;width:81.46%;height:6.0%'><span style=3D'font-family:Arial; font-size:88%;text-shadow:auto'>fear conditioning </span><span style=3D'font-family:Arial;font-size:75%;text-shadow:auto;color:yellow; mso-color-index:7'>(</span><span style=3D'font-family:Arial;font-size:75%; text-shadow:auto;color:yellow;mso-color-index:7'><i>Khuchua et al., 2003</= i></span><span style=3D'font-family:Arial;font-size:75%;text-shadow:auto;color:yellow; mso-color-index:7'>). </span></span></div> <div class=3DCB style=3D'text-align:left;mso-line-spacing:"100 50 0";mso-m= argin-left-alt: 384'><span style=3D'position:absolute;top:66.75%;left:12.73%;width:91.19%; height:6.0%'><span style=3D'font-family:Arial;font-size:88%;color:aqua; text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#FFCC66; mso-color-index:3;position:absolute;left:-7.39%;top:.22em;font-family:Wing= dings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;font-size:8= 8%; text-shadow:auto;color:aqua'>Passive avoidance</span><span style=3D'font-f= amily: Arial;font-size:88%;text-shadow:auto'> affects the distribution of </span>= </span><span style=3D'position:absolute;top:73.0%;left:12.73%;width:95.69%;height:6.0%'= ><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>MAP2-rich modul= es of cortex </span><span style=3D'font-family:Arial;font-size:75%;text-shadow:a= uto; color:yellow;mso-color-index:7'>(</span><span style=3D'font-family:Arial; font-size:75%;text-shadow:auto;color:yellow;mso-color-index:7'><i>Van der = Zee et al., </i></span></span><span style=3D'position:absolute;top:79.0%;left:= 12.73%; width:81.46%;height:5.25%'><span style=3D'font-family:Arial;font-size:75%; text-shadow:auto;color:yellow;mso-color-index:7'><i>1994</i></span><span style=3D'font-family:Arial;font-size:75%;text-shadow:auto;color:yellow; mso-color-index:7'>). </span></span></div> <div class=3DCB style=3D'text-align:left;mso-line-spacing:"100 50 0";mso-m= argin-left-alt: 384'><span style=3D'position:absolute;top:87.5%;left:12.73%;width:95.31%; height:6.0%'><span style=3D'font-family:Arial;font-size:88%;color:aqua; text-shadow:auto'><span style=3D'mso-special-format:bullet;color:#FFCC66; mso-color-index:3;position:absolute;left:-7.07%;top:.22em;font-family:Wing= dings; font-size:80%'>l</span></span><span style=3D'font-family:Arial;font-size:8= 8%; text-shadow:auto;color:aqua'>Spatial and working memory</span><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'> are enhanced b= y </span></span><span style=3D'position:absolute;top:93.75%;left:12.73%;width:89.32%;height:6.0%= '><span style=3D'font-family:Arial;font-size:88%;text-shadow:auto'>overexpression = of kinesin </span><span style=3D'font-family:Arial;font-size:75%;text-shadow:= auto; color:yellow;mso-color-index:7'>(</span><span style=3D'font-family:Arial; font-size:75%;text-shadow:auto;color:yellow;mso-color-index:7'><i>Wong et = al., 2002</i></span><span style=3D'font-family:Arial;font-size:75%;text-shadow:= auto; color:yellow;mso-color-index:7'>).</span></span></div> </div> <div v:shape=3D"_x0000_s20484" class=3DCT><span style=3D'position:absolute; top:-.75%;left:.93%;width:98.12%;height:10.25%'><span style=3D'font-size:1= 09%'>MAP2 and Tubulin Are </span></span><span style=3D'position:absolute;top:10.0%; left:-8.23%;width:116.85%;height:10.25%'><span style=3D'font-size:109%'>Re= organized with Memory Tasks</span><span style=3D'font-size:91%'> </span><span style=3D'font-size:73%;mso-special-format:lastCR;display:none'> </span= ></span></div> </p:slide></div> </body> </html> ------=_NextPart_01C6A98E.B69E84D0 Content-Location: file:///C:/1EF8A2D3/NeuronanotechnologytoCureCriminalityandMentalIllness_files/slide0019.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dus-ascii"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 11"> <link id=3DMain-File rel=3DMain-File href=3D"../NeuronanotechnologytoCureCriminalityandMentalIllness.htm"> <link rel=3DPreview href=3Dpreview.wmf>  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src=3D"slide0019_image005.gif" style=3D'position:absolute;top:0%;left:80.8= 9%; width:19.47%;height:5.25%'><![endif]> <div v:shape=3D"_x0000_s21507" class=3DO><span style=3D'position:absolute; top:70.0%;left:6.92%;width:109.92%;height:5.25%'><span style=3D'font-famil= y: Arial;font-size:83%;text-shadow:auto;color:aqua'>Naïve Control<span style=3D'mso-spacerun:yes'> = ; </span>Tone-Shock Paired<span style=3D'mso-spacerun:yes'> = ; </span>Tone-Shock Unpaired</span><span style=3D'color:#FF0033;mso-color-in= dex: 6'> </span></span><span style=3D'position:absolute;top:75.25%;left:6.92%; width:92.32%;height:5.25%'><span style=3D'color:#FF0033;mso-color-index:6'= ><span style=3D'mso-tab-count:1;width:10.83%'> </span> </span></span> <div style=3D'position:absolute;top:80.75%;left:6.92%;width:92.32%;height:= 6.75%'><span style=3D'color:#FF0033;mso-color-index:6'><span style=3D'mso-tab-count:3; width:32.49%'> </span><span style=3D'mso-spacerun:yes'> </span></spa= n><span style=3D'font-size:133%;color:#FF0033;mso-color-index:6'><span style=3D'ms= o-tab-count: 2;width:19.85%'> </span></span></div> </div> <div v:shape=3D"_x0000_s21508"> <div class=3DO1 style=3D'mso-margin-left-alt:576'></div> <div class=3DO2 style=3D'mso-margin-left-alt:864'></div> <div class=3DO3 style=3D'mso-margin-left-alt:1152'></div> <div class=3DO4 style=3D'mso-margin-left-alt:1440'></div> <div class=3DO style=3D'mso-line-spacing:"100 50 0";mso-margin-left-alt:28= 8'><span style=3D'position:absolute;top:78.75%;left:2.62%;width:108.05%;height:6.0%= '><span style=3D'font-family:Arial;font-size:117%;text-shadow:auto;color:yellow; mso-color-index:7'><span style=3D'mso-spacerun:yes'> &nbs= p; </span>Increased MAP2 immunostaining in hippocampal </span></span><span style=3D'position:absolute;top:85.0%;left:7.67%;width:106.17%;height:6.0%'= ><span style=3D'font-family:Arial;font-size:117%;text-shadow:auto;color:yellow; mso-color-index:7'>CA1 pyramidal cells is due to increased breakdown </spa= n></span><span style=3D'position:absolute;top:91.25%;left:7.67%;width:100.18%;height:6.0%= '><span style=3D'font-family:Arial;font-size:117%;text-shadow:auto;color:yellow; mso-color-index:7'>of these proteins (confirmed by immunoblotting).</span>= </span></div> </div> <div v:shape=3D"_x0000_s21509" class=3DO style=3D'mso-line-spacing:"100 50= 0"; position:absolute;top:1.0%;left:81.83%;width:19.66%;height:3.5%'><span style=3D'font-size:67%;text-shadow:auto'>Woolf et al., 1999</span></div> </p:slide></div> </body> </html> ------=_NextPart_01C6A98E.B69E84D0 Content-Location: file:///C:/1EF8A2D3/NeuronanotechnologytoCureCriminalityandMentalIllness_files/slide0019_image003.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAArEAAAFoBAAAAACgmBGKAAAAAmJLR0QAAKqNIzIAAAAMY21QUEpD bXAwNzEyAAAAB09tt6UAAPRsSURBVHjaXP1tsBxpdh6IdVOKtX/4Rxd6SHqpZYTw0SNpJW6ogQsM JdsR7r4faFqKDXXjVl2MZEdoBreyCkNtBMnGzczCrDYkTaMys0BtUCs26n3zziqGu6tBZSbIGEkh 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